NREMT Paramedic Exam 2025 – 400 Free Practice Questions to Pass the Exam

Cholinergic poisoning occurs when there is an excess of acetylcholine due to inhibition of the enzyme acetylcholinesterase, leading to overstimulation of the parasympathetic nervous system. A potential serious symptom of cholinergic poisoning is seizures, which can result from the significant imbalance and overstimulation within the central nervous system caused by the excessive accumulation of acetylcholine. This overstimulation affects neuronal excitability and can lead to convulsions or seizures as a result of central nervous system involvement.

Bradycardia, dry skin, and dysrhythmias can occur in cholinergic poisoning, but seizures represent a more direct and severe manifestation of the neurological effects of the toxin. Seizures indicate a critical level of distress and dysfunction in the nervous system caused by the toxicological impact of the agents responsible for cholinergic crisis. Understanding these symptoms is crucial for prompt recognition and intervention in cases of poisoning.